Many things that were simple before are far more grueling and troublesome. Take your time to think out your plans, strike with accuracy, and pick your battles. The enemies are far stronger and smarter, so be careful
Scarce resources make the creatures more aggressive and hostile
Hazards like radiation can cause just as  much damage
Meds are the most valuable and rare resource after the great war
Anyone can pose a threat in in the wastland so never let down your guard
Check out the new features added in the Fallout 3 Remastered mod pack...